Endocrine cells of the gastric oxyntic mucosa, and especially the enterochromaffin-like cells (ECL), are the progenitors of gastrin-promoted proliferative lesions whose tumorigenic potential largely depends on the background condition in which they arise.

ECL-celler svarar på gastrin från G-celler och de frisätter histamin vilket stimulerar parietalcellerna att producera magsaft. Sjukdomar[redigera | redigera wikitext].

Gastrin verkar som en trofisk faktor på ECL-cellerna, vilka i sin tur svarar med en hyperplasi och, så småningom, utveckling av polypösa förändringar. ECLom kan producera ett flertal olika hormon och man bör kontrollera P-kromogranin A, U-histaminmetaboliter och U-5HIAA nivåer. ECL cells seems to be similar in different species, there are quantitative differences with regard to the ECL- cell density and possibly also the sensitivity of ECL cells to gastrin. BACKGROUND With the development of substituted benzimid- azoles, an entirely new principle for reducing gastric acid secretion was introduced. Inhibition is achieved Achlorhydria induces G cell hyperplasia and overproduction of gastrin from G cells Increased gastrin stimulates ECL cell hyperplasia in the gastric body (predisposing to well differentiated, type I neuroendocrine tumors) (Clin J Gastroenterol 2019 Nov 28 [Epub ahead of print]) Enterochromaffin-like (ECL) cells, in contrast to EC cells, are confined to a single region of the gut, the gastric fundus, where they form the major endocrine cell population. ECL cells have no lumenal connection (Fig. 6).

Incubation of permeabil-ized ECL cells with micromolar free calcium induces histamine secretion (12). Moreover, gastrin has been shown to induce production of inositol phosphates in ECL cells of Mastomys natalensis (15). These ﬁndings suggest that IP 3 and elevation of [Ca2] i … Thus, no irre- Conceivably, a proliferation of ECL cells to the versible changes in the gastrin or ECL cells were degree found during omeprazole treatment should induced by the omeprazole treatment. occur with any gastric acid secretion inhibitor of similar effectiveness.Thus, when ranitidine was giv- SPECIES DIFFERENCES en by continuous sc infusion (1,200 pmol x kg-' x day-') for 4 weeks Unlike mast cells (Soll et al., 1988), ECL cells respond to gastrin by mobilization of histamine that in turn stimulates acid secretion from parietal cells (Håkanson & Sundler, 1991; Waldum et al., 1991; Andersson et al., 1996).

av A Gagulic · 2012 — Enterochromaffin-like cells / Enterochromaffinlika celler. EE: Erosive esophagitis/ Gastrin stimulerar även enterochromaffinlika (ECL) celler att frisätta histamin.

Keywords:ECL cells, histamine, gastrin, morphology, stomach, enterochromaffin, topology, gastrin stimulation, endocrine, paracrine. Abstract: The term “enterochromaffin cell” was introduced more than 100 years ago.

The ECL cells in the oxyntic mucosa secrete histamine in response to gastrin, stimulating parietal cells to produce acid. Do they also operate under nervous control? The present study examines histamine mobilization from rat stomach ECL cells in situ in response to acute vagal excitation and to food or gastrin following vagal or sympathetic denervation.

Causes of ECLcell histamine plays an important role in the regulation of gastric acid secretion, particularly in response to gastrin stimulation. The timecourse responses of ECL cells to gastrin include mobilization of histamine, hypertrophy, hyperplasia, dysplasia and formation of ECLcell carcinoids.

som högst och beror på samtidig stimulering av ACh, gastrin och histamin (Sjaastad slem- och bikarbonat sekretionen, samt medverkar i cellregenerationen. pantoprazol binder till enzymet distalt om cellreceptorn, kan substansen hämma saltsyrasekretionen oberoende av Fastevärden av gastrin ökar under pantoprazolbehandling. En lätt till måttlig ökning av antalet specifika endokrina (ECL).
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Detta talar för att ECL-cellerna inte produderar något kalciotropt hormon, då celler som producerar dylika hormon borde vara känsliga för förändringar i blod-kalciumnivåerna.

The ECL cells start to proliferate.
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Endocrine cells of the gastric oxyntic mucosa, and especially the enterochromaffin-like cells (ECL), are the progenitors of gastrin-promoted proliferative lesions whose tumorigenic potential largely depends on the background condition in which they arise.. Originating from the histamine-containing enterochromaffin-like (ECL) cells of the embryologic foregut, gastric carcinoid tumors represent

That this sequence of events occurs not only with omeprazole but also with other effective gastric antisecretory agents has been verified in the rat by giving the H2-receptor antagonist ranitidine as a continuous infusion. Gastrin verkar som en trofisk faktor på ECL-cellerna, vilka i sin tur svarar med en hyperplasi och, så småningom, utveckling av polypösa förändringar. ECLom kan producera ett flertal olika hormon och man bör kontrollera P-kromogranin A, U-histaminmetaboliter och U-5HIAA nivåer. ECL cells seems to be similar in different species, there are quantitative differences with regard to the ECL- cell density and possibly also the sensitivity of ECL cells to gastrin.